Cutting Edge: Enhanced Pulmonary Clearance ofPseudomonas aeruginosaby Muc1 Knockout Mice

Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice.

MUC1 (MUC1 in human and Muc1 in nonhumans) is a membrane-tethered mucin that interacts with Pseudomonas aeruginosa (PA) through flagellin. In this study, we compared PA pulmonary clearance and proinflammatory responses by Muc1(-/-) mice with Muc1(+/+) littermates following intranasal instillation of PA or flagellin. Compared with Muc1(+/+) mice, Muc1(-/-) mice showed increased PA clearance, gre...

Knockout Mice Lead to Enhanced Disease Syncytial Virus Clearance in Perforin Alternative Mechanisms of Respiratory

Metastatic Mammary Carcinoma Enhanced Tumor Immunity to Primary and Cutting Edge: STAT6-Deficient Mice Have

Secretory 10-kDa Protein Inflammation in Mice Deficient for Clara Cell Cutting Edge: Altered Pulmonary Eosinophilic

Pulmonary Iron Homeostasis in Hepcidin Knockout Mice

Pulmonary iron excess is deleterious and contributes to a range of chronic and acute inflammatory diseases. Optimal lung iron concentration is maintained through dynamic regulation of iron transport and storage proteins. The iron-regulatory hormone hepcidin is also expressed in the lung. In order to better understand the interactions between iron-associated molecules and the hepcidin-ferroporti...